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Sonne, N., Karsdal, M

This imbalance of the gut microbiota and continued exposure of the colonic epithelial cells to urea is harmful to intestinal epithelial barrier function as it aids the disruption of the mucus layer and lowers the expression of tight junction proteins (Vaziri et al., 2013

Modulating PKM2 expression to control microglial metabolism and suppress neuroinflammation represents a promising therapeutic strategy

Cells were plated on 48-well plates, coated with anti-CD3 (1 g ml 1 ) and anti-CD28 (10 g ml ) antibodies, in RPMI medium or DMEM, supplemented with 10% FCS, penicillin, streptomycin, HEPES, glutamine, pyruvate, nonessential amino acids and -mercaptoethanol diluted with PBS (1:1), in the presence of IL-2 (10 ng ml 1 , Peprotech) and IL-12 (10 ng ml 1 , Peprotech) (T H 1 conditions), with or without amino acids

Concentration of P, S, Na, K, Mg, Ca, Fe, Cu, Zn, Mn, Mo and B were determined by inductively coupled plasma highly dispersive optical emission spectrometry (ICP-OES) according to the method described by 3 (Merck, no

Discovery of novel ortho-aminophenol derivatives targeting lipid peroxidation with potent antiferroptotic activities
