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Therapeutic avenues under investigation include anti-inflammatory and metabolic modulators, senolytics, hormone/secretagogue approaches, and regenerative platforms leveraging stem cells, lacrimal organoids, and bioengineered scaffolds

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Ferroptosis was observed in PAECs from MCT-induced PH rats in vitro and in vivo and was characterized by a decline in cell viability accompanied by increases in the LIP and lipid peroxidation, the downregulation of GPX4 and FTH1 expression and the upregulation of NOX4 expression

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